Abstract
New chalcone and dimeric chalcones with 1,4-p -benzoquinone residue, combrequinone A (1 ), combrequinone B (2 ), and combrequinone C (3 ), along with three known compounds (4 –6 ), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense , and their structures were determined by spectroscopic analysis. Compounds 1 –3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7,
and SW480. Compounds 1, 2 , and 3 were found to be most potent against HL-60 acute leukemia cells, with IC50 values of 4.63, 4.07, and 1.26 µM, respectively.
Key words
Combretum yunnanense
- Combretaceae - combrequinone A - combrequinone B - combrequinone C - cytotoxicity
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Dr. Li-Qin Wang
Department of Chemistry and Chemical Engineering Yunnan Normal University
121 Street
Kunming 650051
Yunnan
People's Republic of China
Phone: +86 87 15 51 60 61
Fax: +86 87 15 51 60 61
Email: lqwang@ynnu.edu.cn
Email: ygchen48@hotmail.com
Dr. Ye-Gao Chen
Department of Chemistry and Chemical Engineering Yunnan Normal University
121 Street
Kunming 650051
Yunnan
People's Republic of China
Phone: +86 87 15 51 60 61
Fax: +86 87 15 51 60 61
Email: ygchen48@hotmail.com